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The macromolecules will be further catabolized in the tumor and stroma into metabolite fuels by processes such as autophagy, nucleic-acid degradation, and even glycogenolysis, by some of the mechanisms outlined below and addressed extensively elsewhere 3,27,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46

However, from basic mechanistic studies to translational applications, numerous critical challenges and unresolved questions remain

Vagbhata A (2007) Uttarasthana, 6th chapter

Cathcart MK, McNally AK, Morel DW et al (1989) Superoxide anion participation in human monocyte-mediated oxidation of low-density lipoprotein and conversion of low-density lipoprotein to a cytotoxin